SYLLABUS OF PHYSICAL PHARMACEUTICS - 2nd(4th Sem Bpharma)

-

                                             SUBJECT

                    PHYSICAL PHARMACEUTICS - 2nd

                              (SUB CODE-BP403T,4th SEM BPHARM,PCI)

UNIT-I 

Colloidal dispersions: Classification of dispersed systems & their general characteristics, size  & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action.



UNIT-II                                                                                             

Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non-Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers

Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus

UNIT-III                                                                                            

Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated   suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of     emulsions and emulsion formulation by HLB method.


UNIT-IV 

Micromeretics: Particle size and distribution, mean particle size, number and weight distribution, particle number, methods for determining particle size by  different methods, counting and separation method, particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties.

UNIT-V 

Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention


Comments

Post a Comment

Popular posts from this blog

Actinomycin D

-
Image
Actinomycin D Actinomycin D is an antibiotic that has potent anti-neoplastic properties. Actinomycin D is also known as Dactinomycin. Dactinomycin is an effective anti-cancerous drug used for the treatment of Wilm's tumor and rhabdomyosarcoma.  Dactinomycin is also effective against certain types of testicular and ovarian cancer. It is also found to be effective against Ewing's sarcoma and metastatic testicular carcinoma. For the cure of choriocarcinoma, dactinomycin is used with combination of methotrexate. Dactinomycin shows its action by causing single-strand breakage of DNA and by blocking RNA transcription due to its interference with template function of DNA. Thus dactinomycin helps in the inhibition of DNA replication and transcription of carcinogenic cells and stops their uncontrolled growth. Dactinomycin is produced by fermentation of Streptomyces parvulus. The structure of dactinomycin contains phenoxazone chromophore and two cyclic peptide chains. The...
Read more

Zidovudine (AZT)

-
Image
Zidovudine (AZT) Zidovudine is an effective anti-viral drug that acts on retroviruses especially human immunodeficiency virus (HIV). It is not preferred 1st line antiviral drug according to regimen 2016 of WHO.  Zidovudine belongs to nucleoside reverse transcriptase inhibitors class of anti-retroviral drugs. The therapeutic dose of zidovudine for adults is 300 mg and 180 mg per meter square for children. Zidovudine is also known as AZT due to its usage as a thymidine analogue. Mechanism of action(MOA):- Zidovudine when administered, get phosphorylation in the host cell and converted into zidovudine triphosphate. The zidovudine triphosphate selectively inhibits viral reverse transcriptase in preference to DNA polymerase. AZT inhibits HIV reverse transcription by replacing thymidine from DNA formed by the reverse transcription process and results in changing of the base sequence of DNA, which makes it an inactive DNA and stops further DNA reverse transcription. Thus zidov...
Read more