Actinomycin D

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Actinomycin D

Actinomycin D is an antibiotic that has potent anti-neoplastic properties. Actinomycin D is also known as Dactinomycin.
Dactinomycin is an effective anti-cancerous drug used for the treatment of Wilm's tumor and rhabdomyosarcoma. 
  • Dactinomycin is also effective against certain types of testicular and ovarian cancer.
  • It is also found to be effective against Ewing's sarcoma and metastatic testicular carcinoma.
  • For the cure of choriocarcinoma, dactinomycin is used with combination of methotrexate.
  • Dactinomycin shows its action by causing single-strand breakage of DNA and by blocking RNA transcription due to its interference with template function of DNA.
  • Thus dactinomycin helps in the inhibition of DNA replication and transcription of carcinogenic cells and stops their uncontrolled growth.
  • Dactinomycin is produced by fermentation of Streptomyces parvulus.
  • The structure of dactinomycin contains phenoxazone chromophore and two cyclic peptide chains.Chemical structure of dactinomycin. | Download Scientific Diagram
  • There are two cyclic chains of amino acids linked with peptide bond.
  • The therapeutic dose of dactinomycin is 15 micrograms per kg of body mass.
  • Dactinomycin is traded in the name of Dacmozen 0.5 mg/vial injection.Dactinomycin Injection Supplier,Wholesaler,Exporter
  • Several adverse effects (side effect) of dactinomycin has been reported, some of them are vomiting, stomatitis, diarrhea, erythema, alopecia, desquamation of skin and bone marrow depression.



Reference- K.D Tripathi Medical Pharmacology 8th Edition.

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