SYLLABUS OF PHARMACEUTICAL ORGANIC CHEMISTRY-3 (4th sem Bpharm)

                                      SUBJECT

        PHARMACEUTICAL ORGANIC CHEMISTRY-3

                        (SUB CODE-BP401T,4th sem ,Bpharm,PCI)

UNIT-I 

• Stereo isomerism Optical isomerism –
• Optical activity, enantiomerism, diastereoisomerism, meso compounds
• Elements of symmetry, chiral and achiral molecules
• DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers
• Reactions of chiral molecules
• Racemic modification and resolution of racemic mixture.
• Asymmetric synthesis: partial and absolute

UNIT-II                                                                                                 

• Geometrical isomerism
• Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
• Methods of determination of configuration of geometrical isomers.
• Conformational isomerism in Ethane, n-Butane and Cyclohexane.
• Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.
• Stereospecific and stereoselective reactions

UNIT-III 

• Heterocyclic compounds:
• Nomenclature and classification
• Synthesis, reactions and medicinal uses of following compounds/derivatives
• Pyrrole, Furan, and Thiophene
• Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

UNIT-IV

• Synthesis, reactions and medicinal uses of following compounds/derivatives
• Pyrazole, Imidazole, Oxazole and Thiazole.
• Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
• Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
• 
  

UNIT-V 

• Reactions of synthetic importance
• Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.
• Oppenauer-oxidation and Dakin reaction.
• Beckmanns rearrangement and Schmidt rearrangement.
• Claisen-Schmidt condensation